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- Unique nanoplatform combines tumor detection and monitoring with potent, light-triggered cancer therapy.
Abu Dhabi, UAE – In a breakthrough in cancer therapeutics, a team of researchers at the Magzoub Biophysics Lab at NYU Abu Dhabi (NYUAD) has made a significant advance in light-based therapies – biocompatible and biodegradable tumor-targeting nanospheres that combine tumor detection and monitoring with potent, light-triggered cancer therapy to dramatically increase the efficacy of existing light-based approaches.
As non-invasive, light-based therapies, photodynamic therapy (PDT) and photothermal therapy (PTT) have the potential to be safe and effective alternatives to conventional cancer treatments, which are beset by a number of issues, including a range of side-effects and post-treatment complications. However, to date, the development of effective light-based technologies for cancer has been hindered by poor solubility, low stability, and lack of tumor specificity, among other challenges. Nanocarriers designed to deliver PDT and PTT more effectively have also proven to have significant limitations.
PDT and PTT utilize different approaches for attacking tumors. PDT uses laser irradiation to activate a photosensitizer to generate reactive oxygen species (ROS), a highly reactive chemical that is toxic to cancer cells. In PTT, a molecule called a photothermal agent converts absorbed light into heat, with the resulting hyperthermia leading to the partial or complete destruction of tumor tissue.
In the paper titled pH-Responsive Upconversion Mesoporous Silica Nanospheres for Combined Multimodal Diagnostic Imaging and Targeted Photodynamic and Photothermal Cancer Therapy, published in the journal ACS Nano, the research team presents the development of acidity-triggered rational membrane (ATRAM) peptide-functionalized, lipid/PEG-coated upconversion mesoporous silica nanospheres (ALUMSNs). These multi-functional, tumor-targeting nanospheres protect encapsulated photosensitizers and photothermal agents from degradation and deliver these molecules directly to cancer cells. The ALUMSNs enable tumor detection and monitoring through thermal and fluorescence imaging, as well as magnetic resonance imaging (MRI). The ALUMSNs also facilitate near-infrared (NIR) laser light-induced PDT and PTT, which in combination improves the efficacy of both phototherapies to shrink tumors with no detectable systemic toxicity.
“Because ROS is a highly reactive molecule with a very short lifetime and a limited radius of action, it is imperative that a sufficient amount of the photosensitizer molecule is present in the tumor tissue for PDT to be effective,” explained Loganathan Palanikumar, NYUAD research scientist and a senior researcher in the Magzoub lab. “In addition, the localized hyperthermia required for PTT is dependent on significant accumulation of photothermal agents within tumors.” The ability of the nanocarriers developed by the NYUAD team to increase the efficiency at which photosensitizers and photothermal agents are delivered to the tumor is a critical advance.
“New therapeutic approaches are desperately needed to enhance the existing arsenal of cancer-fighting treatments,” said Mazin Magzoub, NYUAD associate professor of biology, whose lab focuses on developing novel therapeutics and drug delivery systems. “The multifunctional core-shell nanospheres our team has developed help to overcome issues that have limited the efficacy of key light-based therapies, offering a promising tumor-targeting nanoplatform that facilitates multimodal diagnostic imaging and potent combinatorial cancer therapy. This work opens up an exciting path forward for the advancement of light-based cancer treatments.”
About NYU Abu Dhabi
NYU Abu Dhabi is the first comprehensive liberal arts and research campus in the Middle East to be operated abroad by a major American research university. NYU Abu Dhabi has integrated a highly selective program with majors in the sciences, engineering, social sciences, arts, and humanities with a world center for advanced research. Its campus enables students to succeed in an increasingly interdependent world, and to advance cooperation and progress on humanity’s shared challenges. NYU Abu Dhabi’s high-achieving students have come from some 120 countries and speak over 115 languages. Together, NYU's campuses in New York, Abu Dhabi, and Shanghai form the backbone of a unique global university, giving faculty and students opportunities to experience varied learning environments and immersion in other cultures at one or more of the numerous study-abroad sites NYU maintains on six continents.
